Genetic variation and the HapMap Project I
نویسنده
چکیده
منابع مشابه
Perspectives on Human Genetic Variation from the HapMap Project
The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibrium in a sample of 270 individuals across four geographical populations. In total, over one milli...
متن کاملAlgorithms for Haplotype Inference and Block Partitioning
The completion of the human genome project in 2003 paved the way for studies to better understand and catalog variation in the human genome. The International HapMap Project was started in 2002 with the aim of identifying genetic variation in the human genome and studying the distribution of genetic variation across populations of individuals. The information collected by the HapMap project wil...
متن کاملLatest HapMap update aims to direct researchers to genetic basis of disease.
When scientists decoded the human genome, they produced the genetic blueprint for an abstract, generic individual who doesn't really exist. Compiled from a few anonymous samples, the DNA sequence derived by the Human Genome Project represented a typical human but offered few insights into the genetic variation that drives individual features, such as physical appearance and disease susceptibili...
متن کاملTransferability of Tag SNPs to Capture Common Genetic Variation in DNA Repair Genes Across Multiple Populations
Genetic association studies can be made more cost-effective by exploiting linkage disequilibrium patterns between nearby single-nucleotide polymorphisms (SNPs). The International HapMap Project now offers a dense SNP map across the human genome in four population samples. One question is how well tag SNPs chosen from a resource like HapMap can capture common variation in independent disease sam...
متن کاملIdentification of Deletion Polymorphisms from Haplotypes
Numerous efforts are underway to catalog genetic variation in human populations. While the majority of studies of genetic variation have focused on single base pair differences between individuals, i.e. single nucleotide polymorphisms (SNPs), several recent studies have demonstrated that larger scale structural variation including copy number polymorphisms and inversion polymorphisms are also c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003